br Introduction At the end of the last

Introduction
At the end of the last century, the World Health Organization introduced relevant provisions on obesity, regarding that obesity is a disease. In recent years, with the continuous improvement of people’s living standards and change in dietary structure, incidence of obesity has shown an increasing trend and obesity has become a serious health killer. Relevant research shows that obesity is often accompanied with chronic Angiogenesis Compound Library and emergence of oxidative stress in patients. Tumor necrosis factor-α is the major protein associated with obesity, which plays a very important role in regulating body fat metabolism (Suo and Wang, 2015). Obesity can cause serious increase in vivo tumor necrosis factor α content in patients. Research at this stage considers that this phenomenon is mainly related to low-grade inflammation and natural immunity (Liu and Liu, 2012). The author conducted meticulous research on 120 male SD rats, and applied rat test results in human clinical therapy (Song et al., 2014). The structure chart of tumor necrosis factor α is shown in Fig. 1.

Materials and methods

Results

Discussion and conclusion

Acknowledgments
The research was supported by Shenzhen city science and technology research and development projects. Topic: Research on the relationship between diet induced obesity rat bile acids and intestinal microflora. Number: JCYJ20130402112843373.

Introduction
Nephrology disease is kidney based disease of many patients. Nephrology diseases mainly include acute nephritis, chronic kidney disease and urinary tract infections. Nephrology disease can lead Angiogenesis Compound Library to decline in patients’ own immune system, resulting in poor application condition of patients and serious infections. Urinary tract infection is a common infection of nephrology disease, which causes a very serious impact on health of patients with nephrology disease. Therefore, analysis of pathogen distribution of nephrology patients with urinary tract infection should be strengthened, so as to realize diagnosis and treatment of urinary tract infection, and effectively improve treatment of urinary tract infections, which can promote effective recovery of nephrology patients with urinary tract infection. The pathogens under microscope is shown in Fig. 1.

Materials and methods

Results

Discussion and conclusion
All in all, pathogen distribution of nephrology patients with urinary tract infections shows certain characteristics. E. coli is one of the most important pathogens. Study of distribution of pathogens and necessary analysis of drug resistance in patients can provide some guidance for clinical treatment work, enable patients to receive effective treatment, and prevent disease progression in patients and thus is with very significant clinical significance.

Introduction
Sepsis, a common complication of burn, trauma, hypoxia, and post-surgery, is a systemic inflammatory response syndrome caused by infection (Tjardes and Neugebauer, 2002; Lever and Mackenzie, 2007). With relatively high morbidity mortality, sepsis is considered to be the leading cause of death of patient in theintensivecareunit (ICU) (Tjardes and Neugebauer, 2002; Levy et al., 2001; Angus and van der Poll, 2013). Multiple organ function impairment may occur at severe sepsis and ultimately develop to multiple organ dysfunction syndrome (Marshould, 2001). Lung is one of the most vulnerableorgans at sepsis with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) which occurs at early stage and is with high morbidity (Hudson et al., 1995; Husak et al., 2010; Angus et al., 2001). The severe pulmonary inflammation, vascular permeability, diffuses infiltration in both lungs, and pulmonary alveoli edema, hypoxemia and lungcompliance decrease are the characteristics for ALI (Villar et al., 2011). Both intra pulmonary factors and extrinsic pulmonary factors make contribution to the pathogenesis of ALI/ARDS. The intra factors include aspirationpneumonia, severe diffuse lung infection, pulmonary contusion, and extrinsic factors include sepsis caused by extrinsic pulmonary infection, wound shock and burn (Brun-Buisson et al., 2004; Gattinoni et al., 1998; Sheu et al., 2010). Among these, sepsis is the most common cause of ALI (Suntharalingam et al., 2001; Rocco and Zin, 2005). Currently, there are still no effective drugs and therapies for the treatment of sepsis-associated ALI/ARDS. The main method is supportive treatment such as mechanicalventilation for respiration support. However, increasing evidence has demonstrated that mechanical ventilation brings damage to organs when improving the oxygenation for the patients. Mechanical tension caused by excessive mechanicalventilation, is an important cause for lung injury (Rocco and Zin, 2005; Martin et al., 2003) and could often cause inflammation in lungs. Therefore, development for new method of curing ALI caused by sepsis other than mechanicalventilation is imperative.