• APPL is highly expressed in pancreatic cells but

  2024-10-10

  

  APPL1 is highly expressed in pancreatic β cells, but its levels are significantly decreased in several mouse models of obesity and diabetes, including HFD-induced obese mice and db/db mice [6], [73], suggesting that the dysregulation of APPL1 may be associated with malfunction of the pancreas in obe

• SB525334 Two patients developed diffuse mesangio proliferati

  2024-10-09

  

  Two patients developed diffuse mesangio-proliferative glomerulonephritis (DMPG) postoperatively, presenting as nephrotic syndrome and benign haematuria, respectively. DMPG has been reported in an adult patient with thymomatous MG following thymectomy [35], and various types of glomerulonephritis hav

• Despite functional studies demonstrating the role of HT

  2024-10-09

  

  Despite functional studies demonstrating the role of 5-HT in ureteral contractility, the source of endogenous 5-HT in the ureter is unclear. Since 5-HT-containing enterochromaffin cells, which are present in the gastrointestinal tract, could not be found in the ureter (Nocito et al., 2007, Ripoche,

• An AXL decoy receptor with enhanced GAS binding

  2024-10-09

  

  An AXL decoy receptor with enhanced GAS6-binding properties, MYD1, was engineered as a therapeutic tool to disrupt GAS6/AXL signaling in vivo (Kariolis et al., 2014). MYD1 was shown to block metastasis of human ovarian cancer adenosine deaminase inhibitor and a murine breast cancer cell line in graf

• Biotin-HPDP The synthesis of compounds in

  2024-10-09

  

  The synthesis of compounds in which the ethyl linker has been modified to the carbamate and urea derivatives , and is shown in . Thus the diamine was reacted with glycolic Biotin-HPDP to give the alcohol followed by Mitsunobu reaction with phthalimide to give . Deprotection with hydrazine gave the

• The present study indicates elevated ATX activity as a highl

  2024-10-09

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In urat1 inhibitor to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared a

• Therefore the rational design of target compounds is based o

  2024-10-09

  

  Therefore, the rational design of target compounds is based on the hybrid of attractive phenotypic bis-indole (5, Fig. 1) and sulfonamide moieties, in which the indole core might anticipate in hydrophobic interaction, and the functionality of sulfonamide group may involve in H-bonding with the site

• As the experimental procedure used could reflect agonist sti

  2024-10-09

  

  As the experimental procedure used could reflect agonist-stimulation of both anterograde and retrograde APJ trafficking, as has been described for the δ-opioid peptide receptor (Zhang et al., 2006b, Zhang et al., 2006a), receptor internalization was more directly monitored by loading cell surface HA

• Assessment of antibiotic appropriateness is receiving increa

  2024-10-09

  

  Assessment of antibiotic appropriateness is receiving increased attention in the face of growing concerns about the emergence of MDROs, as well as the rise in adverse outcomes associated with antibiotic use such as C. difficile infection. In this study, 15% of cultured Gram-negative organisms met th

• What are the in situ effects of multi site

  2024-10-09

  

  What are the in-situ effects of multi-site CaM associations with AT1R? Kai et al. showed that synthetic peptides corresponding to residues 125–137 (rat sequence) in SMD2, 217–227 in the N-terminal side of SMD3, and 304–316 in SMD4JM inhibit to various degrees AngII-induced GTPase activity of isolate

• Besides the described changes in protein

  2024-10-09

  

  Besides the described changes in protein expression and thus in current amplitudes, Kinase Inhibitor Library of PORCN also leads to accelerated decay kinetics of evoked and spontaneous AMPAR currents. These changes in channel kinetics are most likely a secondary effect due to the selective depletion

• When arachidonic acid is used as a substrate

  2024-10-09

  

  When arachidonic Magnolol is used as a substrate, the platelet-type 12S-lipoxygenase produces predominantly the 12S-hydroperoxy derivative. In contrast, the leukocyte-type 12S-lipoxygenases generate substantial amounts of the 15-lipoxygenase product in addition to the 12S-hydroperoxy derivative. Th

• For the first series we decided

  2024-10-08

  

  For the first series we decided to verify the effects induced, on the ALR2 inhibitory properties, of an additional steric hindrance on the carbon in α position with respect to the carboxylic group, by introducing a methyl group (R2=Me). Therefore, we synthesized a series of new α-alanine derivatives

• Aldose reductase ALR EC the first enzyme in the

  2024-10-08

  

  Aldose reductase (ALR2, EC1.1.1.21), the first enzyme in the polyol pathway, is a monomeric oxidoreductase that catalyses the NADPH-dependent reduction of a wide variety of carbonyl compounds, especially glucose. In this metabolism pathway, glucose is firstly reduced to sorbitol catalyzed by ALR2 wi

• As regards feeding the ability to dissipate surplus

  2024-10-08

  

  As regards feeding, the ability to dissipate surplus energy in the form of heat is beneficial for animals if the protein concentration in the food is low, since it allows them then to meet the adequate protein intake requirement without getting fat. Some of the major dietary activators of the AHR ar

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