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RA plays an instrumental role in neuronal differentiation
2018-10-29
RA plays an instrumental role in neuronal differentiation and neuronal patterning as well as motor axon generation. In addition, RA is required for the maintenance of mature adult neurons (reviewed in Ferri et al., 2007). Various concentrations of RA (from 1 to 10μM) have been used to induce ESCs in
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In our model DNA damage forces cells into
2018-10-29
In our model, DNA damage forces cells into cellular senescence, whereas ATM-dependent and p53-antagonized cytokine secretion activates BMP2/JAK-STAT signaling and stimulates the differentiation process in a progressive feed-forward manner. This senescent state is very different from the GFAP-associa
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br Materials and methods br Results br Discussion Using a
2018-10-26
Materials and methods Results Discussion Using a dual-promoter lentivirus-transduced BM-HSC transplantation model, we report here that both transgenes (i.e. murine invariant chain (Ii) and the GFP reporter) can be detected in various APC cell types from different organs (Fig. 1). Thus, this
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Results br Discussion In this
2018-10-26
Results Discussion In this study, we described the differentiation of hiPSCs into efficient functional ECs and compared them with hESC-ECs. We have found that hiPSCs, similar to hESCs, can be differentiated into ECs by the use of a sequential combination of FLK1-positive (EPC marker) and CD31-po
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In demyelinating diseases injury of myelin oligodendrocytes
2018-10-26
In demyelinating diseases, injury of myelin/oligodendrocytes results in a profound loss of myelin sheaths, axonal injury and degeneration, which eventually lead to long-lasting functional disabilities (Franklin and Ffrench-Constant, 2008; Emery, 2010). Mouse models of oligodendrocyte injury, such as
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br Results br Discussion The data presented herein substanti
2018-10-26
Results Discussion The data presented herein substantially expand the potential of developing CSC-targeted therapy based on inhibition of the SUMO pathway. We show that inhibition of sumoylation by knockdown of UBC9 and PIAS1 effectively repressed expression of MMP14 and CD44, reduced invasive
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br Experimental Procedures br Author
2018-10-26
Experimental Procedures Author Contributions Acknowledgments P.W.B. received funding through the Alborada Trust\'s support of the Alzheimer\'s Research UK Stem Cell Research Centre. J.S. was supported by the Innovative Medicines Initiative Consortium, StemBANCC (grant no, 115439). H.Z. was
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The underlying idea of the tomographic method is
2018-10-26
The underlying idea of the tomographic method is in reconstructing f(x, y), i.e. the density distribution function (or distribution of any other quantity) in the plane [3]. The initial data are sets of Radon images Rφ(s) that are projections of the functions f(x, y) on the set of the corresponding s
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br Experimental Thiophene aniline and titanium chloride
2018-10-26
Experimental Thiophene, aniline and titanium chloride (TiCl4) were purchased from SD fine, India. AR grade were used as starting chemicals, without further purification. The TiCl4 was used as an oxidizing agent to initiate the chemical polymerization. The random copolymer of PTh-co-PANI-Ti was sy
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br Conclusion To summarize we have developed a method
2018-10-26
Conclusion To summarize, we have developed a method for determining Young\'s modulus of the sample surface using an AFM with an optical system for detecting the position of the probe organized by the interferometric principle. We have obtained the temperature dependence for the spring constant of
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The existence of similar charged particle trajectories in th
2018-10-26
The existence of similar charged particle trajectories in these fields due to the property of homogeneity allows to create analyzers with multi-channel registration of charged particles with respect to energy (electric spectrographs) or mass number (magnetic spectrographs). In the last 10 years, a n
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tnf alpha inhibitors More immediate factors may also be
2018-10-26
More immediate factors may also be important mediators through which family wealth may influence young adult mental health. One possible mechanism is by facilitating higher educational attainment, which is strongly related to mental health in young adults (Adams, Knopf, & Park, 2014). Indeed, some s
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Our study focuses on urban governance that
2018-10-26
Our study focuses on urban governance that involves policies of local governments and provision of public goods and services. In accordance with federal and state authorities, many local agencies are established primarily at the county level. The delegation of authority to local governments, especia
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Thus even though these two
2018-10-26
Thus, even though these two phenomena – PE and/or NDO – may be more prevalent in the youngest group, they may not have strong adverse health effects over time, because individuals advance, or expect to advance in their careers. Those who were in less desired and more precarious employment in their
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Table shows results from models partitioned by sex
2018-10-26
Table 4 shows results from models partitioned by sex. In congo red to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at migration. This
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